Zolpidem is a hypnotic, belonging to the group of imidazopyridines, and is a selective agonist of the subclass of omega-benzodiazepine receptors. It has a sedative effect, while it does not have anxiolytic, central muscle relaxant and anticonvulsant effects when used in usual doses. Shortens the time of falling asleep, reduces the number of nocturnal awakenings, increases the total duration of sleep and improves its quality. Lengthens the II stage of sleep and the stage of deep sleep (III and IV). Does not cause drowsiness during the day. You can Buy Zolpidem 5mg 28 Tablets online UK without prescription in our online pharmacy.
Selective agonist of the omega-subtype of benzodiazepine receptors of macromolecular GABA-receptor complex. It interacts with the central omega-receptors, localized mainly in the cerebellum, certain areas of the cortex (IV layer of the sensitive-motor cortical zones), the black substance, the lower hillock, the olfactory bulb, the ventral part of the thalamic complex, the bridge and the pale ball in the central nervous system. Increases the sensitivity of GABA receptors to the mediator (GABA), which leads to an increase in the opening frequency in the cytoplasmic membrane of the neurons of the channels for the incoming currents of chloride ions, hyperpolarization of the synaptic membrane, increased inhibitory effect of GABA, and inhibition of neuronal activity in various parts of the central nervous system.
Sleep disorders: difficulty falling asleep, early and night awakenings.
Acute and / or severe respiratory failure; severe acute or chronic liver failure; night apnea (including supposed); in connection with the presence of lactose: hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome; pregnancy; lactation period; children’s age (up to 18 years); increased sensitivity to zolpidem or other component of the drug.
Dosing and Administration
Inside (immediately before bed) in a single dose of 10 mg. In elderly or debilitated patients, if liver function is impaired, treatment is started with a dose of 5 mg. If necessary (insufficient clinical effect) and good tolerability of the drug, the dose may be increased to 10 mg. The maximum daily dose is 10 mg. The course of treatment should not exceed 4 weeks. With transient insomnia, the recommended course of treatment is 2-5 days, in case of a situational one – 2-3 weeks.
Possible: confusion, memory impairment, visual impairment, nightmarish dreams, drowsiness, headaches, dizziness, gait disturbance, agitation; abdominal pain, nausea, vomiting, diarrhea; skin rash, itching; with prolonged use, development of dependence is not ruled out.
Interaction with alcohol. It is forbidden to drink alcoholic beverages during the drug intake.
You should be careful when using the drug for people with respiratory and liver failure. During the drug should refrain from engaging in potentially hazardous activities that require increased attention (driving, working at height, with mechanisms). The drug is able to enhance the effect of other drugs that depress the central nervous system.
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